Modified polio vaccine helps fight deadly brain tumors .

Modified polio vaccine helps fight deadly brain tumor

Modified polio vaccine helps fight deadly brain tumors

Some patients with 'dismal' prognosis were alive as long as six years later

A modified version of the polio vaccine, infused straight into aggressive brain tumors, helped some patients live for years longer than they normally

It’s no miracle cure — only about 20 percent of patients with gliomas were helped — but some are alive six years later

It’s a hopeful enough finding to move forward and test the vaccine in more people.

Standard treatment of brain tumors includes surgery if the tumor is somewhere reachable; chemotherapy; and radiation. But if the tumor is aggressive, it’s usually fatal.

These are people who failed everything,” Bigner said. “Virtually all patients, no matter what you treat them with, are dead within in two years.”

About a third of all brain tumors are gliomas, according to the Brain Tumor Society. About 80,000 people a year are diagnosed with a brain tumor, and about 24,000 of those are malignant. “The average survival rate for all malignant brain tumor patients is only 34.7 percent,”

But there’s evidence that some viruses can home in on tumors and kill them. It’s not clear why, but viruses can also make tumors more visible to the immune system.

They infused various doses into the tumors of the 61 glioma patients.

“We inject the virus directly into brain tumors and it kills all the tumor cells it comes in contact with,” Bigner said. “The most important thing is, it sets up a secondary immune response and really destroys the distant tumor cells.”

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